Fenofibrate Inhibits LPS and Zymosan-induced Inflammatory Responses through Sonic Hedgehog in IMG Cells
Our findings suggest that fenofibrate may inhibit inflammatory responses by activating SIRT1 and SHH in IMG microglial cells. Our study suggests that fenofibrate or targeting SHH molecule is a promising therapeutic strategy for neuroinflammation-associated conditions. Further research with additional cell lines and in vivo models is needed to understand its therapeutic potential.
Authors
- Bor‐Ren Huang
- Liang‐Yo Yang
- Jin-Wun Chen
- Vichuda Charoensaensuk (ORCID: https://orcid.org/0000-0001-7706-0464)
- Wei‐Lan Yeh
- Dah‐Yuu Lu (ORCID: https://orcid.org/0000-0002-4463-5919)
- Cheng‐Fang Tsai
- Sheng‐Wei Lai
- Y. Wang
Institutions
- Asia University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- Yuanpei University (TW)
Publication Details
- Journal
- Current Molecular Pharmacology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.2174/0118761429317532241017051135
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Science Council
- China Medical University Hospital
- China Medical University, Taiwan