Expert Recommendations on the Use of a New Hyaluronic Acid Injectable for the Aesthetic Treatment of the Chin and Lower Face

The Restylane® portfolio of hyaluronic acid (HA) fillers comprises a broad range of products, each with a unique combination of gel strength/firmness and flexibility. Restylane® Shaype™ (HASHA) is a new HA injectable produced with NASHA-HD™ technology and the most recent addition to the Restylane portfolio. NASHA-HD is an evolution of the NASHA™ platform that adds more HA and uses a more efficient cross-linking even though the degree of modification is kept low. HASHA has an HA-concentration of 25 mg/mL and a G prime (G') of 916 Pa (0.1 Hz). Experts recommend using HASHA for treatment in the chin area because its high G' allows a higher degree of correction/projection with lower injection volumes, especially in those patients with pronounced chin retrusion, together with a long duration of effect and good overall safety. Depending on the patient's needs and the aim of treatment, different approaches and injection techniques should be applied. This paper reflects the recommendations of an interdisciplinary expert panel for the use of HASHA for the correction of the chin area, including patient selection, product volume, product placement, injection technique, and post-treatment care. Recommendations were discussed and agreed as a consensus, according to cross-sectional expertise and clinical experience.   J Drugs Dermatol. 2025;24(1):70-78. doi:10.36849/JDD.8593.