Thermomechanical analysis of a pharmaceutical composition in the form of sponges

Introduction. The attractiveness of polymer-based application medicinal products lies in the fact that these dosage forms have a number of advantages over traditional ones: due to pharmaceutical factors, it is possible to achieve therapeutic effects using small doses of the active pharmaceutical ingredient; reduce/avoid side effects of the active pharmaceutical ingredient, regulate the pharmacokinetics of the drug (modified release of the active pharmaceutical ingredient). Given the wide range of applications of application medicines, it is relevant and timely to develop a methodology and make strategic decisions to provide the population with competitive domestic application medicines which requires the study of their thermomechanical characteristics. Such dosage forms as dermatological films and medicinal/medical/hemostatic sponges have a theoretical basis for practical development and prospects for industrial production. These dosage forms can be implemented in the extemporaneous production of pharmacies, which is very important especially in the context of military operations and emergencies. Purpose. Conducting thermomechanical analysis of a pharmaceutical composition in the form of sponges to further substantiate the technology of their manufacture. Materials and methods. Thermomechanical analysis of the samples was performed using a laboratory thermomechanical analyzer. The thermomechanical analysis of the deformation of composites under the influence of load and temperature was performed in the penetration mode, in the temperature range of 20-250 oC with a constant heating rate of 5 oC/min. The diameter of the indenter pressing on the specimen was 3 mm with a load of 5 g, which creates a load on the specimen of ~7 kPa. Results. Our test was conducted on model samples of pharmaceutical composition and placebo. The alignment of the curves occurs at a temperature of 200 oС. In this study, thermal expansion of the material with increasing temperature was not recorded. Conclusions. Thermomechanical analysis showed that the deformation behavior of the pharmaceutical formulation and placebo was similar. The difference observed in the initial deformation is due to the porosity of the sample structure. It was proved that thermal expansion of the material does not occur with increasing temperature. It was found that the approximate value of the melting point of the model samples is ~215 °C. Above a temperature of 250 °C, no complete extrusion of the sample is observed. At this temperature, the deformation reaches 78 %.