Anticancer Studies of Iraqi-cultivated Cydonia Oblonga From the Family of Rosaceae

Background: Cydonia oblonga Miller is a plant that provides numerous phytochemical benefits that could be used in medicine, such as flavones, flavonols, and their glycosides, in addition to different vitamins and minerals. Objectives: This study evaluates the in vitro cytotoxic activity of C. oblonga ethyl acetate of two plant parts (fruit and seeds) against human colon cancer cells (Caco-2) using the MTT assay method. Methods: In this study, two parts of the C. oblonga plant were used (seeds and fruit) and extracted by using different organic solvents, such as 98% hexane, 80% ethanol, and ethyl acetate. The ethyl acetate extract of both parts was used to evaluate the cytotoxic activity of C. oblonga on human colon cancer cells (Caco-2) by using the MTT assay method. Results: The ethyl acetate extract of seeds had no considerable cytotoxic effect (P>0.1), while the fruit extract showed a significantly high antiproliferative effect compared to the oxaliplatin anticancer drug (P<0.1). Conclusion: The fruit ethyl acetate extract of the quince plant gives significant anticancer activity against colon cancer cells as compared to seed extract which showed no effect.