Course of the first trimester and the condition of the immune system in pregnant women after application of the assisted reproductive technologies

Pregnancy, which is a consequence of the assisted reproductive technologies (ART) application, takes place in specific conditions and is accompanied by numerous complications. One of the factors’ causing infertility is disorders in the immune system (IC), which lead to a pregnancy complication. Aim - to evaluate the course of the first trimester of pregnancy and determine the state of the immune system in women with tubal-peritoneal infertility whose pregnancy occurred application of the ART. Materials and methods. 94 women with tubo-peritoneal type of infertility, whose pregnancy occurred as a result ART application, who formed the main group and 50 pregnant women with spontaneous onset and physiological course of pregnancy, who formed the control group, were examined. In addition, determination of the immunological link of homeostasis in all women was performed. Results. In the first trimester of pregnancy in the main group women took place changes in the T-cell IC link, which was reflected in an increase in the number of CD3+ cells and a decrease in the number of CD8+ cells, which indicated the first degree of immune disorders. Examination of the humoral link in the main group pregnant women revealed a decrease in CD22+ cells, an increase in their absolute number together with an increase in the concentration of IgM and decrease in the concentration of IgG. Conclusions. When analyzing the immune system in pregnant women with tubo-peritoneal type of infertility, a tendency to the formation of immune disorders in both the cellular and humoral links of the immune system due to an increase in the absolute and relative number of T-lymphocytes and a decrease in B-lymphocytes, an increase in the concentration of IgM and a decrease in the concentration of IgG, was established. confirms the activation of cellular and humoral links of the immune system. The study was conducted in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the local ethics committee of the participating institution. Informed consent was obtained from all patients. No conflict of interests was declared by the authors.