HPV-associated cervical intraepithelial neoplasia: treatment and rehabilitation in perimenopausal women

Optimization of postoperative rehabilitation of women with recurrent of cervical intraepithelial neoplasia (CIN) II contributes to a decrease in the frequency of postoperative complications and an increase in the efficiency of cervical epithelialization. The aim is to reduce the frequency of complications after destructive treatment of recurrent CIN in perimenopausal women. Materials and methods. 60 HPV-positive perimenopausal women with verified recurrent CIN II were examined. After radiowave conization, vaginal suppositories with extracts of centella asiatica seeds, calendula officinalis, aloe, tea tree essential oil; hyaluronic acid were prescribed in the Group I (n=30); vaginal suppositories with methyluracil - in the Group II (n=30). The effectiveness was assessed based on complaints, clinical manifestations, degree and duration of cervical epithelialization and complications at 6 weeks and 3 months after treatment. Results. The high level of subjective comfort feeling at the 6th after operation in the Group I was 86.7% versus 63,4% in the Group II; at the 3rd month - 100% versus 83.3%, respectively. Pain, bloody vaginal discharge, lymphorrhea during the first 1-3 days of the postoperative period and during scab rejection on the 10-15th day were observed in 3-6% of women (Group I) versus 23-26.7% (Group II). A high degree of cervical epithelialization in the Group I occurred on 33.4±1.9 days versus 44.5±3.1 days in the Group II. Conclusions. Radiowave conization in combination with a blend of herbal extracts for local application proves the high effectiveness of rehabilitation of women with recurrent CIN II compared to traditional management tactics. The study was conducted in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the local ethics committee of the participating institution. Informed consent was obtained from all patients. No conflict of interests was declared by the authors.