Anti-Alzheimer effects of the newly synthesized cationic compounds as multi-target dual hAChE/hBuChE inhibitor: An <i>in silico, in vitro</i>, and <i>in vivo</i> approach
The novel quaternary ammonium derivative, compound 5g, demonstrated multi-target anti-AD properties, as evidenced by <i>in silico, in vitro</i> and <i>in vivo</i> studies. Behavioral assessments and molecular analyses further confirmed its therapeutic efficacy in amyloid-beta (Aβ)-challenged rats.
Authors
- Roghaye Nikbakht
- Somaieh Soltani (ORCID: https://orcid.org/0000-0002-0102-2960)
- Farzaneh Narimani
- Saeed Sadigh‐Eteghad (ORCID: https://orcid.org/0000-0003-2872-1072)
- Reza Teimuri‐Mofrad (ORCID: https://orcid.org/0000-0002-5812-6445)
- Hosna Karami (ORCID: https://orcid.org/0000-0003-4732-9850)
- Mohammad‐Reza Rashidi (ORCID: https://orcid.org/0000-0001-9206-9336)
- Hanieh Farrokhi
- Gerhard Wolber (ORCID: https://orcid.org/0000-0002-5344-0048)
Institutions
- Tabriz University of Medical Sciences (IR)
- University of Tabriz (IR)
- Sadra Institute Of Higher Education (IR)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Bioimpacts
- Published
- 2024-12-29
- DOI
- https://doi.org/10.34172/bi.24196
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Medical Research Development