Impact of Creatine Kinase Levels on Lymphocytes and Premature Aging in Five Localities in West Cameroon

Background: This study investigates the relationship between creatine kinase (CK) levels and lymphocyte populations in elderly individuals across five localities in West Cameroon. CK, a muscle enzyme, may be associated with immune imbalances that contribute to premature aging. Methods: A cross-sectional study included 768 participants aged 50 years and older. CK and lymphocyte counts were measured and categorized as hypoCKaemia, normoCKaemia, and hyperCKaemia for CK, and lymphopenia, normal, and lymphocytosis for lymphocytes. Multivariate regression analyses were conducted to assess these associations, controlling for age, sex, socio-economic factors, and nutritional variables. Results: HypoCKaemia was significantly associated with lymphopenia, while hyperCKaemia correlated with lymphocytosis. Individuals aged ≥70 years exhibited higher prevalence rates of these imbalances. Socio-economic status, dietary habits, and geographic variations significantly influenced the observed patterns. Conclusions: Monitoring CK and lymphocyte levels is essential for identifying risks of premature aging and immune imbalances. Targeted interventions focusing on physical activity, nutrition, and addressing socio-economic disparities could improve muscle and immune health in elderly populations.