Synergistic associations of CD33 variants and hypertension with poor cognitive function, brain atrophy, and cerebral blood flow among dementia‐free older adults: a population‐based study
The current study reveals the synergistic associations of immune-related CD33 rs3865444 and HTN with low cognitive function and brain atrophy in dementia-free older adults. These joint effects of HTN and CD33 on cognition may be related to the disruption of CBF and blood brain barrier function.
Authors
- Xiaodong Han (ORCID: https://orcid.org/0000-0002-6546-7993)
- Lin Song (ORCID: https://orcid.org/0000-0001-9500-8387)
- Na Tian (ORCID: https://orcid.org/0000-0001-5627-5095)
- Yifeng Du
- Chengxuan Qiu (ORCID: https://orcid.org/0000-0003-1922-4912)
- Min Zhu (ORCID: https://orcid.org/0000-0002-7468-0083)
- Lin Cong
- Yongxiang Wang (ORCID: https://orcid.org/0000-0002-2003-6006)
- Cuicui Liu (ORCID: https://orcid.org/0000-0002-5960-5851)
- Shi Tang
- Tingting Hou (ORCID: https://orcid.org/0000-0003-2614-8145)
- Xunyao Tian
- Heng Zhang (ORCID: https://orcid.org/0009-0007-6751-7062)
Institutions
- Shandong University (CN)
- Stockholm University (SE)
- Capital Medical University (CN)
- Karolinska Institutet (SE)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088540
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00