Reelin gene therapy promotes cognitive resilience in a mouse model of amyloid induced tauopathy

We conclude that ICV injections of AAV expressing a bio-active fragment of reelin can partially protect against cognitive impairment in a mouse model of amyloid induced tauopathy. This is consistent with a potential protective role of reelin signaling in Alzheimer's disease. While we did not observe an effect of R36 over-expression on tau pathology, we do demonstrate a significant reduction of insoluble Aβ42. We continue to investigate additional chemical and histological markers in these mice to better understand the protective influence of reelin.