Aging x Environment x genetic risk for late onset Alzheimer’s disease results in alterations in cognitive function in mice independent of amyloid and tau pathology
These data are the first reports of cognitive deficits and neurophysiological alterations in mice with environmental x genetic risk for LOAD, independent of amyloid and tau pathology. Importantly, the present findings demonstrate the sensitivity of the translational touchscreen testing battery for detecting mild cognitive impairment in LOAD mice with corresponding neurophysiologic alterations, and extend previous characterization data for the LOAD2 model and its utility for the study of the biology of LOAD.
Authors
- Sean-Paul G. Williams (ORCID: https://orcid.org/0000-0002-5680-7730)
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Diogo Francisco da Silva dos Santos (ORCID: https://orcid.org/0000-0003-3306-2147)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Kathryn A. Haynes (ORCID: https://orcid.org/0000-0002-5064-6905)
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Bruce T. Lamb (ORCID: https://orcid.org/0000-0001-8507-2561)
- Cynthia M. Ingraham
- Adrian L. Oblak (ORCID: https://orcid.org/0000-0003-1210-8791)
- Scott C. Persohn (ORCID: https://orcid.org/0000-0001-5047-8238)
- Stacey J. Sukoff Rizzo (ORCID: https://orcid.org/0000-0002-1460-8127)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Nicholas S. Heaton (ORCID: https://orcid.org/0000-0002-5307-3428)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Kierra Eldridge
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Nian Wang (ORCID: https://orcid.org/0000-0001-7743-0728)
- Christopher D Lloyd
- Jason T Hart
Institutions
- University of Pittsburgh (US)
- Neurosciences Institute (US)
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093301
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00