Genotyping transposable element insertions and their novel application in gene mapping strategies for Alzheimer’s disease (AD) endophenotypes

Our pragmatic approach using existing WGS data to genotype endogenous regulatory units for studying genetic underpinnings of preclinical AD markers identifies putatively novel disease-causal genes with clear biological function. As a proof of concept, our approach highlights the scope of extending to other cohorts and AD related neurodegenerative disorders.