Autologous macrophages stimulated by epoxides of polyunsaturated fatty acids and protected by inhibitors of soluble epoxide hydrolase or cGAS/STING pathway repair amyloid‐β pathology in the Alzheimer’s disease (AD) brain
Inhibiting macrophage inflammation by the sEH receptor inhibitors TPPU and EC5026 or the STING inhibitor H-151 in AD macrophages could restore cognition in AD patients.
Authors
- Milan Fiala (ORCID: https://orcid.org/0000-0001-8023-6053)
- Bruce D. Hammock (ORCID: https://orcid.org/0000-0003-1408-8317)
- Santosh Kesari (ORCID: https://orcid.org/0000-0003-3772-6000)
- Julian P. Whitelegge (ORCID: https://orcid.org/0000-0003-2763-7733)
Institutions
- University of California, Los Angeles (US)
- UCLA Health (US)
- Pacific Heart Institute (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085616
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00