Truncated tau accumulates before hyperphosphorylated tau and in relatively distinct neuronal subpopulations in entorhinal cortex and inferior temporal gyrus in Alzheimer’s disease patients
Neuronal D13 tr-tau deposits develop in AD before p-tau pathology. Across AD Braak stages, the % of overlapping between D13 tr-tau and p-tau positive neuronal populations is moderate at best; these results suggest neuronal accumulation of D13 tr-tau occurs in a selectively vulnerable manner. This corroborates D13 tr-tau as a potential biomarker of tau pathology in AD overlooked by p-tau screening. Future plans include analysis of these pathological markers between clinically typical and atypical variants of AD.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Felipe Luiz Pereira (ORCID: https://orcid.org/0000-0001-9326-2365)
- Roberta Diehl Rodriguez (ORCID: https://orcid.org/0000-0002-6544-7861)
- Ian Oh
- Song Hua Li
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Andrew J. Ambrose (ORCID: https://orcid.org/0000-0002-2932-4514)
- Michelle R. Arkin (ORCID: https://orcid.org/0000-0002-9366-6770)
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Prabhleen Kaur (ORCID: https://orcid.org/0000-0002-6994-9914)
- Anya Raju
- William W. Seeley
- Rushil Jerfy
Institutions
- Berkeley College (US)
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Global Brain Health Institute (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093137
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33