Clusters of modifiable risk factors provide resilience to the cognitive effects of β‐amyloid pathology in aging
Favorable risk profiles (cluster 1 and 2) attenuated the effect of Aβ, but not tau, on cognitive decline. These findings suggest that different risk profiles moderate pathology-cognition relationships, and demonstrate that different factors may operate together in reducing risk. This highlights the role of groups of modifiable resilience factors in mitigating the effects of Aβ deposition.
Authors
- Joseph Giorgio (ORCID: https://orcid.org/0000-0003-3704-5977)
- Stefania Pezzoli (ORCID: https://orcid.org/0000-0002-2429-7334)
- Tyler J. Ward (ORCID: https://orcid.org/0000-0002-4681-8137)
- William Jagust
- Susan M. Landau
- Mohini Bhade
Institutions
- Lawrence Berkeley National Laboratory (US)
- University of Newcastle Australia (AU)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090877
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00