Associations among mild behavioral impairment symptoms, brain pathology and cognition in individuals with autosomal‐dominant Alzheimer’s disease: Findings from the Colombia‐Boston (COLBOS) biomarker study
Findings suggest that NPS captured by MBI-C are associated with pathology and memory in a Colombian kindred with autosomal dominant AD, years before the median age of dementia onset in this cohort. This underscores the importance of behavioral symptoms in preclinical and prodromal ADAD. Follow-up analyses with larger samples and longitudinal assessments are needed to characterize neuropsychiatric symptom evolution as an early marker and target for intervention.
Authors
- Diana Munera
- Daniel Vásquez (ORCID: https://orcid.org/0000-0002-2586-162X)
- Ana Baena (ORCID: https://orcid.org/0000-0002-5622-4519)
- Victoria Zubiri
- Francisco Lopera (ORCID: https://orcid.org/0000-0003-3986-1484)
- David Fernando Aguillon (ORCID: https://orcid.org/0000-0003-2283-536X)
- Martin Ochoa‐Escudero (ORCID: https://orcid.org/0000-0003-3933-3622)
- Alex L Badillo‐Cabrera
- Jennifer R. Gatchel (ORCID: https://orcid.org/0000-0002-3892-9742)
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Stephanie Langella (ORCID: https://orcid.org/0000-0001-6082-5491)
- Sergio Álvarez (ORCID: https://orcid.org/0000-0003-4983-0892)
- Clara Vila‐Castelar (ORCID: https://orcid.org/0000-0002-8779-1487)
- Cláudia Ramos (ORCID: https://orcid.org/0000-0002-0030-4501)
- Averi Giudicessi
- Jairo E. Martínez (ORCID: https://orcid.org/0000-0002-5888-481X)
- Elizabeth Kaplan
- Nikole A Bonillas Félix
- Liliana A Ramirez Gomez
- Celina F. Pluim McDowell
Institutions
- Harvard University (US)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- Hospital Pablo Tobon Uribe (CO)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088002
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00