Repetitive injury causes Alzheimer’s disease‐like phenotypes via reactivation of HSV‐1 in a 3D human brain tissue model
We suggest that after brain injury from repeated mechanical blows in life, the resulting HSV-1 reactivation in the brain leads to the development of AD/dementia, i.e., that HSV-1 is a major cause of AD. We hope to discover ways of alleviating the effects of TBI-induced HSV-1 reactivation that ultimately lead to AD, and whether other types of brain damage cause similar effects.
Authors
- Marilyn Kelly
- David L. Kaplan (ORCID: https://orcid.org/0000-0002-9245-7774)
- Dana M. Cairns (ORCID: https://orcid.org/0000-0003-0574-8395)
- Jordan A. Smiley (ORCID: https://orcid.org/0009-0004-9537-0465)
- Ruth F. Itzhaki (ORCID: https://orcid.org/0000-0001-5167-5276)
- Brooke M. Smiley (ORCID: https://orcid.org/0000-0001-9000-3931)
- Yasaman A Khorsandian
Institutions
- Tufts University (US)
- University of Manchester (GB)
- University of Oxford (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089702
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00