Discrepancy between Apolipoprotein E genotyping and proteotyping as a result of a nonsense mutation
ApoE4 proteotyping offers advantages over genotyping by determining the effective presence of the protein in plasma, especially in case of mutations affecting the expression or function of the protein. Also, quantifying ApoE protein levels via immunoassays could yield insights into the relation of ApoE protein levels with pathology. Moreover, in case of potential future applications in a laboratory workflow, molecular testing could possibly be avoided, offering advantages in terms of turn-around-time and logistics.
Authors
- Caroline Dobbels
- Kristel Sleegers (ORCID: https://orcid.org/0000-0002-0283-2332)
- Rosina Degrieck
- Katsumi Aoyagi (ORCID: https://orcid.org/0000-0003-3818-7985)
- Tatsushi Yuri
- Hisashi Nojima (ORCID: https://orcid.org/0000-0002-8907-5767)
- Fahri Küçükali (ORCID: https://orcid.org/0000-0002-3835-9639)
- Ina Vandenbroucke
- Jo Kamada
- Dagmara Minczakiewicz (ORCID: https://orcid.org/0009-0005-2996-6698)
- Jasper Van Dongen
Institutions
- VIB-UAntwerp Center for Molecular Neurology (BE)
- Fujirebio (Japan) (JP)
- Fujirebio (Belgium) (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088844
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65