Microglial Activation Alters Chromatin Accessibility of AD‐Associated Transcription Factors
Microglial activation by specific inflammatory stimuli causes epigenetic rewiring, resulting in differential accessibility of AD-associated transcription factors and altered response to future stimuli. In this way, microglial activation and IIM may later contribute to microglial dysfunction in AD pathogenesis.
Authors
- Zena K. Chatila (ORCID: https://orcid.org/0000-0002-4383-6305)
- Jason Mares
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Elizabeth M. Bradshaw (ORCID: https://orcid.org/0000-0002-6766-4325)
- Wassim Elyaman (ORCID: https://orcid.org/0000-0001-7238-374X)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
Institutions
- Columbia University Irving Medical Center (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085990
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00