The association between tau pathology and later stages of memory processing is mediated by medial temporal lobe atrophy in typical Alzheimer’s Disease
The results suggest that MTL tau pathology, partially mediated by macrostructural changes, lead to impairments in specific memory domains in early AD. Impairments in fluency and executive functioning, however, seem more likely to follow from tau-induced effects in neocortical regions.
Authors
- Long Xie (ORCID: https://orcid.org/0000-0002-7184-7028)
- Salena Cui
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Laura E.M. Wisse (ORCID: https://orcid.org/0000-0001-7504-3943)
- Anika Wuestefeld (ORCID: https://orcid.org/0000-0003-1779-3388)
- Paul A. Yushkevich (ORCID: https://orcid.org/0000-0001-8543-4016)
- Emily McGrew
Institutions
- Lund University (SE)
- Siemens (United States) (US)
- Siemens Healthcare (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087337
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00