Proteomics identification of novel proteins dysregulated in Alzheimer’s Disease with potential as blood‐based biomarkers and related to Amyloid‐Beta Plaques
The dysregulation of selected targets in AD patients was confirmed at protein level in a different cohort of tissue samples. Importantly, two proteins showed potential as blood-based diagnostic biomarkers of AD, and eighteen candidate proteins were validated as novel Abeta plaques interactors, highlighting a major role of these proteins in AD development and progression.
Authors
- Isabel Liste (ORCID: https://orcid.org/0000-0002-3294-9558)
- Vivian de los Rı́os (ORCID: https://orcid.org/0000-0001-5582-6879)
- Rodrigo Barderas (ORCID: https://orcid.org/0000-0003-3539-7469)
- Ana Montero‐Calle (ORCID: https://orcid.org/0000-0001-5141-0454)
- Raquel Coronel (ORCID: https://orcid.org/0000-0002-1156-2151)
- Javier Martínez‐Useros (ORCID: https://orcid.org/0000-0001-9007-828X)
- Marta Mendes (ORCID: https://orcid.org/0000-0002-3528-7123)
- Alberto Peláez‐García (ORCID: https://orcid.org/0000-0002-5401-3216)
- María Jesús Fernández‐Aceñero (ORCID: https://orcid.org/0000-0002-2439-3553)
Institutions
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Clínico San Carlos (ES)
- Escuela Nacional de Sanidad (ES)
- Luxembourg Institute of Health (LU)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Centro de Investigaciones Biológicas Margarita Salas (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086675
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00