Unveiling the Role of A2AR Dysregulation in Olfactory Dysfunction and Amyloidogenesis in Alzheimer’s Disease
This study underscores the pivotal role of A2AR dysregulation in olfactory dysfunction associated with AD. The observed tight binding of A2AR with APP implies its direct involvement in Aβ formation. These findings highlight the significance of A2AR dysregulation in olfactory dysfunction and amyloidogenesis, suggesting novel therapeutic targets and early diagnosis for AD intervention.
Authors
- Shigeru Kakuta (ORCID: https://orcid.org/0000-0002-5900-1425)
- Eerdunfu Eerdunfu
- Lan Bao (ORCID: https://orcid.org/0000-0001-9269-9565)
- AILIYA AILIYA
- XIJIRI XIJIRI
Institutions
- The University of Tokyo (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092055
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00