Multi‐omics QTL provide insights into cell specific effects on molecular functions and intermediate traits in Alzheimer’s disease and its iPSC‐derived model systems

Our findings highlight how the FunGen xQTL integrated resource facilitates the discovery and elaboration of the causal chain linking a genetic variant to a series of molecular phenotypes and ultimately a clinical syndrome. We will gradually expand this foundation to map how AD loci interact with one another to perturb the molecular state of the brain and eventually lead to cognitive decline.