Reduced plasma nicotinamide level and altered NAD<sup>+</sup> metabolism in glial cells surrounding Aβ plaques in the mouse model of Alzheimer’s disease
This study suggests that alterations in plasma nicotinamide levels may be a potential biomarker to assess neuroinflammatory response against Aβ pathology and "nicotinate and nicotinamide metabolism" may be a potential therapeutic target to prevent the onset of AD by targeting both neuroinflammation and neuroprotection.
Authors
- Kimi Takei
- Sachie Chikamatsu
- Risa Nishijima
- Michiko Sekiya (ORCID: https://orcid.org/0000-0001-8275-8293)
- Yu Hirota (ORCID: https://orcid.org/0000-0002-7107-2197)
- Yasufumi Sakakibara (ORCID: https://orcid.org/0000-0002-7459-1611)
- Naoki Ito (ORCID: https://orcid.org/0009-0003-8182-7471)
- Koichi Iijima (ORCID: https://orcid.org/0000-0003-4794-1863)
Institutions
- Japan Society for the Promotion of Science (JP)
- Nagoya City University (JP)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088847
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.16