Exploring the Impact of Race, African Ancestry, and APOE4 on Sex Differences in Amyloid Pathology and Cognitive Outcomes in an Admixed Population‐Based Neuropathological Sample
Women exhibited increased susceptibility to amyloid pathology, resulting in more pronounced cognitive impairment, suggesting that sex-specific genetic, biological, and sociocultural factors may play a role in women's higher AD vulnerability.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Carlos Augusto Pasqualucci (ORCID: https://orcid.org/0000-0001-6608-2473)
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Ricardo Nitríni (ORCID: https://orcid.org/0000-0002-5721-1525)
- Maison Abu Raya (ORCID: https://orcid.org/0000-0002-7272-2104)
- Wilson Jacob Filho (ORCID: https://orcid.org/0000-0003-2290-4492)
Institutions
- Universidade de São Paulo (BR)
- University Memory and Aging Center (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Global Brain Health Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093140
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00