Examining the shared genetic liability between late‐life onset psychosis and major psychiatric, cognitive and personality phenotypes

In early life, psychosis is known to overall with cognitive, psychiatric and personality traits. These data extend this observation to later-life psychosis. The significance of the differences between self and informant reported symptoms are yet to be determined but may be a mix of measurement error and the different respondents having a propensity to report symptoms which reflect different etiologies. We also show that established protective factors against cognitive decline, like educational attainment, in later life may also extend to late life neuropsychiatric syndrome.