Uncovering mechanisms of hyperexcitability in tauopathies with functional genomics
Functional genomics screens are being developed to identify modifiers of excitability in disease and healthy neurons. Further screening and validation experiments will reveal mechanisms that lead to hyperexcitability in tauopathies and potential targets for therapeutic intervention.
Authors
- Jesse E. Hanson (ORCID: https://orcid.org/0000-0003-3059-5132)
- Ying‐hui Chou (ORCID: https://orcid.org/0000-0003-0707-286X)
- Ming‐Chi Tsai (ORCID: https://orcid.org/0000-0002-6216-8672)
- Steven Boggess (ORCID: https://orcid.org/0000-0001-9232-4122)
- Martin Kampmann (ORCID: https://orcid.org/0000-0002-3819-7019)
- Vaidehi Gandhi
Institutions
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Chan Zuckerberg Initiative (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.083573
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00