The neurophysiological effects of frontotemporal lobar degeneration: linking synaptic loss, network connectivity and cognitive decline
MEG, PET and MRI are each well tolerated by people with PSP/bvFTD. These methods indicate severe and progressive synaptic loss, more than atrophy, with resulting behaviourally-relevant changes in prefrontal network beta-power and connectivity. Biophysical modelling confirms in vivo the post mortem observation of superficial cortical vulnerability to PSP/bvFTD.
Authors
- James Benedict Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
Institutions
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087315
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00