The anti‐platelet agent prasugrel reverses the cerebral blood flow deficit and memory impairment induced by hypertension in ApoE4‐positive mice
Paralleling human findings, we show that mice with the e4 allele of ApoE experience more deleterious consequences from hypertension, as compared to their e3 counterparts. Prasugrel treatment led to an almost complete recovery of these deficits, suggesting that anti-platelet agents may be of therapeutic value by improving CBF and cognitive function in the presence of these risk factors.
Authors
- J Bernard
- Costantino Iadecola (ORCID: https://orcid.org/0000-0001-9797-073X)
- Nathaniel H. Allan‐Rahill (ORCID: https://orcid.org/0000-0002-8090-8339)
- Nicole E. Chernavsky (ORCID: https://orcid.org/0009-0008-4128-0498)
- Robert D. Hawkins (ORCID: https://orcid.org/0000-0001-9089-8544)
- Nozomi Nishimura (ORCID: https://orcid.org/0000-0003-4342-9416)
- Kenya Yamaguchi (ORCID: https://orcid.org/0000-0001-8632-4169)
- Chris B. Schaffer (ORCID: https://orcid.org/0000-0002-7800-9596)
- Lianne J. Trigiani (ORCID: https://orcid.org/0000-0002-6332-7903)
- Michael R. E. Lamont (ORCID: https://orcid.org/0000-0002-2933-0842)
- Green Bae (ORCID: https://orcid.org/0000-0003-3894-4958)
- Daniel Rivera (ORCID: https://orcid.org/0000-0002-4558-7402)
- Amanda Huang (ORCID: https://orcid.org/0000-0001-6393-5282)
- Rachel Kim (ORCID: https://orcid.org/0000-0003-3135-0196)
- Nuri Hong
Institutions
- Cornell University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088400
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00