Spastic paraplegia leading PSEN1‐related familial Alzheimer’s disease in Italy
The outcomes of this study increase the clinical and mutational landscape associated with PSEN1-related familial AD. Expanding results of different populations, we strongly recommend PSEN1 genetic testing in affected subjects having SP with no variants in known HSP-related genes, mostly when linked with a family history of AD.
Authors
- Emanuele Panza (ORCID: https://orcid.org/0000-0002-2338-1139)
- Antonio Orlacchio (ORCID: https://orcid.org/0000-0002-2602-3281)
- Arun Meyyazhagan (ORCID: https://orcid.org/0000-0002-1934-3906)
- Toshitaka Kawarai (ORCID: https://orcid.org/0000-0002-0091-6647)
- Preethi Basavaraju (ORCID: https://orcid.org/0000-0001-7097-2276)
- Marialuisa Miele
Institutions
- Bharathiar University (IN)
- University of Perugia (IT)
- Azienda Ospedaliero Universitaria San Giovanni Battista (IT)
- Azienda USL di Bologna (IT)
- Himeji Medical Center (JP)
- Fondazione Santa Lucia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089719
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00