AD Pathology Spreading Detection Using Directional Motifs in Brain Connectomes
Our results suggest that the progression of toxic tau through the brain systems occurs mainly in a unidirectional and serial manner. AD is considered a dysconnectivity disease. Thus, serial motifs could indicate biological relations arising on a sequential spatiotemporal scale. Future developments will examine the role of amyloid accumulation in tau progression in the context of AD.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Jorge Sepulcre (ORCID: https://orcid.org/0000-0002-4199-2304)
- Elisenda Bueichekú (ORCID: https://orcid.org/0000-0002-3059-9806)
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Andrés Úbeda (ORCID: https://orcid.org/0000-0003-3223-025X)
- Chan Mi Kim (ORCID: https://orcid.org/0000-0001-5686-1668)
Institutions
- Harvard University (US)
- Yale Cancer Center (US)
- Yale University (US)
- Maastricht University (NL)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088834
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00