Heterogeneous clinical phenotypes of sporadic Early‐onset Alzheimer’s disease: A data‐driven approach
Applying a neuropsychological data-driven method of phenotyping EOAD individuals uncovered a more detailed understanding of the diversity of presenting heterogeneity in this atypical AD group compared to clinical judgment alone. These results suggest that clinicians and patients may over-prioritize memory dysfunction during subjective reporting at the expense of non-memory symptoms, which has important implications for diagnostic accuracy and treatment considerations. We plan to investigate the patterns of cortical atrophy and network dysfunction subserving this heterogeneity.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Deepti Putcha (ORCID: https://orcid.org/0000-0001-5575-5572)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Yuta Katsumi (ORCID: https://orcid.org/0000-0003-0413-747X)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
Institutions
- Alzheimer's Association (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Brown University (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091639
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00