Alzheimer’s disease multiomic signatures mediated by Cholesterol Ester Transfer Protein
These findings indicate that both CETP and APOE influence total PC and are associated with molecular pathways of immune activation and amyloid biology. Overall this evidence suggests that CETP and APOE act on shared pathways, likely mediated by lipid metabolism and peripheral immunity, that contribute to AD susceptibility.
Authors
- Ted Abel (ORCID: https://orcid.org/0000-0003-2423-4592)
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Catrina Spruce
- Тетяна Полякова (ORCID: https://orcid.org/0000-0002-3353-2228)
- Cheryl L. Wellington (ORCID: https://orcid.org/0000-0001-7014-039X)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
Institutions
- Tufts University (US)
- University of British Columbia (CA)
- Jackson Laboratory (US)
- University of Maine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090912
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.57