Distinct mouse models correspond to distinct AD molecular subtypes
In this study, we highlighted that mouse model of AD may match to a particular subset of human AD subtypes but not all subtypes simultaneously, and that risk for these subtypes may be influenced by distinct AD genetic factors. Additional work toward validating and better understanding the role of each subtype key regulator in its matching mouse model will provide great value and have a great impact on future studies of AD.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Bruce T. Lamb (ORCID: https://orcid.org/0000-0001-8507-2561)
- Adrian L. Oblak (ORCID: https://orcid.org/0000-0003-1210-8791)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
Institutions
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087565
- Citations
- 1
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.23