Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis
While the enhancer landscapes of iPSC-derived neuronal and glial cells vary in similarity to their ex vivo counterparts, they display similar ND risk SNP enrichments in cell type-specific enhancers, suggesting that disease risk SNP mechanisms are largely recapitulated in iPSC-derived cells. The iMGL epigenome is notably similar to ex vivo microglia, and CRISPRi screening of AD and MS risk loci in these cells will advance our understanding of these diseases and nominate potential therapeutic targets.
Authors
- George W. Bell (ORCID: https://orcid.org/0000-0001-6826-2507)
- Olivia Corradin (ORCID: https://orcid.org/0000-0002-9484-0873)
- Zeynep Gökçe Gayretli Aydın (ORCID: https://orcid.org/0000-0003-4291-1067)
- Rudolf Jaenisch (ORCID: https://orcid.org/0000-0002-2540-7099)
- Michael D. Gallagher
- Yiran Cheng (ORCID: https://orcid.org/0000-0001-5589-2024)
- Katheryn EA Hazel
- Wenjuan Du
- Bingbing Yuan (ORCID: https://orcid.org/0000-0002-8460-5124)
- Richard A. Young
Institutions
- Whitehead Institute for Biomedical Research (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093591
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25