Genetic factors affect tau deposition in entorhinal cortex and neocortex
Genetic factors affect tau pathological burden above and beyond the effects of Aβ. Both females and APOE-ε4 homozygotes express tau deposition in the EC at lower Aβ CL than males and non-homozygotes. Neocortical tau deposition is related to EC tau and is greater in APOE-ε4 homozygotes and individuals with a genetic risk for impaired neuroinflammatory responses. These findings may explain variable effects of anti-amyloid treatments and provide insights into the potential biological drivers of tau spread.
Authors
- Joseph Giorgio (ORCID: https://orcid.org/0000-0003-3704-5977)
- Jingshen Wang (ORCID: https://orcid.org/0000-0002-1432-3834)
- William J. Jagust (ORCID: https://orcid.org/0000-0002-4458-113X)
- Jennifer S. Yokoyama (ORCID: https://orcid.org/0000-0001-7274-2634)
- Caroline Warly Solsberg
- Yilin Wang
Institutions
- University of Iowa (US)
- Lawrence Berkeley National Laboratory (US)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- University of Newcastle Australia (AU)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084883
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00