Intranasal <i>Chlamydia pneumoniae</i> Infection Induces Neuroinflammation and Cognitive Decline in Mice
Intranasal Cp infection leads to brain colonization and altered Iba1 immunoreactivity. Both primary astrocytes and microglia support Cp growth and produce neuroinflammatory cytokines. Long-term Cp infection promotes neuroinflammation and cognitive decline in mice along with increased Aβ deposits. Cognitive impairment in Cp-infected ADtg and WT mice as well as increased Aβ in ADtg mice suggest that Cp infection may play an important pathological role in AD development.
Authors
- Lalita Subedi (ORCID: https://orcid.org/0000-0003-4851-7650)
- Malcolm Lane
- Moshe Arditi (ORCID: https://orcid.org/0000-0001-9042-2909)
- Bhakta Prasad Gaire (ORCID: https://orcid.org/0000-0002-9738-6493)
- Timothy R. Crother (ORCID: https://orcid.org/0000-0001-8465-6127)
- Jean‐Philippe Vit (ORCID: https://orcid.org/0000-0001-5057-8554)
- Dieu‐Trang Fuchs
- Maya Koronyo‐Hamaoui (ORCID: https://orcid.org/0000-0003-2864-8442)
- Daisy Martinon
- Shuang Chen (ORCID: https://orcid.org/0000-0002-2919-4967)
- Monica Mita
- Yosef Koronyo
Institutions
- Cedars-Sinai Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.083564
- Citations
- 1
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.34