Cerebellar and cerebral contributions to social inference impairments in early stages of Alzheimer’s disease

These results clarify that in early-stage AD, cerebellar involvement and its interaction with corresponding cerebral regions may play a more important role in socioemotional processing than previously appreciated. Specifically, left-lateralized cerebellar and right-lateralized cerebral damage predicted poorer social inference understanding in persons with AD. Their emotion reading, in contrast, involved cerebellar and cerebral hemispheres more bilaterally.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.091928
Primary Topic
Psychosomatic Disorders and Their Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Cerebellar and cerebral contributions to social inference impairments in early stages of Alzheimer’s disease

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Alzheimer s & Dementia
Psychosomatic Disorders and Their Treatments
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Cerebellar and cerebral contributions to social inference impairments in early stages of Alzheimer’s disease

Myrthe G. Rijpma, Rea Antoniou, Yu Chen, Bailey McEachen, Bruce L. Miller, Howard J. Rosen, Katherine P. Rankin, Joel H. Kramer, Faatimah Syed
article en

Abstract

These results clarify that in early-stage AD, cerebellar involvement and its interaction with corresponding cerebral regions may play a more important role in socioemotional processing than previously appreciated. Specifically, left-lateralized cerebellar and right-lateralized cerebral damage predicted poorer social inference understanding in persons with AD. Their emotion reading, in contrast, involved cerebellar and cerebral hemispheres more bilaterally.

Alzheimer s & DementiaVol. 20(S3)
University of California, San Francisco (US)
Quality Education
Openalex Percentile: Top 66%
Psychosomatic Disorders and Their Treatments
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