Second‐Generation Epigenetic Clocks and Socioeconomic Status Predict Midlife Cognitive Status
Second-generation DNAm age measures show promise in their predictive value for cognitive aging processes. Moreover, the longitudinal twin design of the LTS serves as a quasi-experimental framework to investigate hypothesized causal effects of DNAm on cognitive aging. Finally, our findings related to childhood SES suggest that the epigenome is malleable and responsive to early-life stressors.
Authors
- Christopher R. Beam (ORCID: https://orcid.org/0000-0001-6827-409X)
- Deborah Winders Davis (ORCID: https://orcid.org/0000-0002-5943-3877)
- Sophie A. Bell (ORCID: https://orcid.org/0000-0003-2658-2419)
- Deborah Finkel (ORCID: https://orcid.org/0000-0003-2346-2470)
- Ariel King
- Lesa Ryan
- Eric Turkheimer (ORCID: https://orcid.org/0000-0002-3493-6398)
- Amelia Cevelle Barna
- Kendra Sikes
Institutions
- University of Southern California (US)
- University of Louisville (US)
- Norton Healthcare (US)
- University of Virginia (US)
- Jönköping University (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093357
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00