Shared and distinct molecular signatures of astrocyte subtypes across brain regions and neurodegenerative diseases

We identified astrocyte subpopulations shared across all the brain regions and disease conditions with shared molecular marker genes but also regional- or disease-specific gene expression features. We also observed disease- or brain region-specific astrocyte subpopulations. These results suggest that regional differences in astrocyte subpopulations or gene expression could underly regional differences in brain susceptibility to different neurodegenerative diseases.