Pathologically confirmed advanced stage of limbic predominant age related TDP‐43 encephalopathy (LATE): A case report

In this report, the subject was initially diagnosed with Alzheimer's dementia while alive; however, a post-mortem autopsy revealed the primary condition to be an advanced stage of LATE, specifically at Joseph stage 6, coexisting with Alzheimer's disease and cerebrovascular pathology. This case underscores the importance of understanding the pathological characteristics of TDP-43 protein abnormalities and their related clinical manifestations.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.092271
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Pathologically confirmed advanced stage of limbic predominant age related TDP‐43 encephalopathy (LATE): A case report

Sung‐Hye Park, Jin Hwan H Lee, Young Hee Jung
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Pathologically confirmed advanced stage of limbic predominant age related TDP‐43 encephalopathy (LATE): A case report

Sung‐Hye Park, Jin Hwan H Lee, Young Hee Jung
article en

Abstract

In this report, the subject was initially diagnosed with Alzheimer's dementia while alive; however, a post-mortem autopsy revealed the primary condition to be an advanced stage of LATE, specifically at Joseph stage 6, coexisting with Alzheimer's disease and cerebrovascular pathology. This case underscores the importance of understanding the pathological characteristics of TDP-43 protein abnormalities and their related clinical manifestations.

Alzheimer s & DementiaVol. 20(S1)
Seoul National University (KR), Myongji Hospital (KR), Hanyang University (KR)
Good health and well-being
Openalex Percentile: Top 65%
Alzheimer's disease research and treatments
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