Comprehensive Clinical and Neuropathological Analysis of Down Syndrome Over Seven Decades of Life
This case report provides a comprehensive look into the clinical and neuropathological correlates of DS and documents unique clinical and pathological changes over 7 decades of life. We also explored hypotheses and potential mechanisms underlying increased lifespan in certain DS individuals despite progressive intellectual impairment and neurodegenerative pathologies.
Authors
- Vanessa Goodwill (ORCID: https://orcid.org/0000-0001-7665-7146)
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Jennifer Ngolab (ORCID: https://orcid.org/0000-0002-3482-0299)
- Michael S. Rafii (ORCID: https://orcid.org/0000-0003-2640-2094)
- Sahar Salehi (ORCID: https://orcid.org/0009-0005-2968-8077)
- Annie OF Hiniker (ORCID: https://orcid.org/0000-0002-0055-6610)
- Ha Yeon Kim (ORCID: https://orcid.org/0000-0001-7468-1310)
- Sonal Sukreet
- Solana Leisher
Institutions
- University of Southern California (US)
- Autism Research Institute (US)
- University of California San Diego (US)
- Southern States University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092874
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00