Anti‐saccadic task can distinguish between patients at risk of developing Alzheimer’s disease and cognitively unimpaired patients in a memory clinic

A brief anti-saccadic task was able to distinguish between individuals with and without brain atrophies, with PoE capturing atrophy grade with largest effect size. Similarly, the task distinguished individuals with better and worse cognition, with LoCS resulting in largest effect sizes. Our results indicate that both PoE and LoCS have a potential to distinguish individuals at risk of ADD from cognitively unimpaired individuals. Furthermore, the lack of CSF association raises questions about chronology of pathological processes involved in AD.