Investigating the Role of Mitochondrial DNA in Alzheimer’s Disease Biomarker Expression
Cytoplasmic hybrid cell lines generated with mtDNA from individuals with and without AD express diagnostic differences in novel AD biomarkers. This suggests that mitochondrial function, specifically that which is influenced by mtDNA, plays an imperative role in AD pathology. Ongoing research in the cybrid cell model will help elucidate how altered cellular and bioenergetic function contribute to AD etiology.
Authors
- Paul J. Kueck (ORCID: https://orcid.org/0000-0002-9102-2058)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Heather Wilkins (ORCID: https://orcid.org/0000-0003-4563-4544)
- Ian W. Weidling (ORCID: https://orcid.org/0009-0009-5277-7149)
- Chelsea N. Johnson (ORCID: https://orcid.org/0000-0003-2827-3265)
- Russell Howard Swerdlow (ORCID: https://orcid.org/0000-0003-2948-7230)
- Riley E. Kemna
- Casey S. John
Institutions
- University of Kansas (US)
- AbbVie (United States) (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092424
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00