Cell type specific contributions of mTOR inhibition that drive neuroprotective mechanisms in Alzheimer’s disease
The present interim results confirm and extend the protective effects of ubiquitous reduction of mTOR expression. Ongoing studies in Cre+ lines will determine in which cell types reduced mTOR signaling is necessary for neuroprotection by comprehensive characterization of these models in functional assessments, AD biomarkers and relevant pathology.
Authors
- Sean-Paul G. Williams (ORCID: https://orcid.org/0000-0002-5680-7730)
- Diogo Francisco da Silva dos Santos (ORCID: https://orcid.org/0000-0003-3306-2147)
- Toren Finkel (ORCID: https://orcid.org/0000-0002-0726-3546)
- Stacey J. Sukoff Rizzo (ORCID: https://orcid.org/0000-0002-1460-8127)
- Aman Reddy
- Jason T Hart
- Amy Lehman
- Kathryn A. Haynes
- Seana E Eckels
- Umesh Nepali
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092635
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00