Manifold Component Analysis: a novel technique to spatially profile tau tangles across Alzheimer’s disease stages
The MCA method proves useful as an intuitive lookup tool for tau tangle accumulation across the brain in AD. The obtained profiles help resolve correspondence between "space" and "time" contexts of the pathology spread, as well as the spatial aspect of the timeline of cognitive decline. As MCA is a subject-specific, easily applicable, fast and extensible technique, numerous new applications and extensions will follow, providing a necessary aid in staging, forecasting, and potentially treating AD.
Authors
- Yasser Iturria‐Medina (ORCID: https://orcid.org/0000-0002-9345-0347)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Paolo Vitali (ORCID: https://orcid.org/0000-0001-8953-1542)
- Mélissa Savard
- Min Su Kang
- Gassan Massarweh (ORCID: https://orcid.org/0000-0003-2259-9627)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Stijn Servaes (ORCID: https://orcid.org/0000-0002-4431-957X)
- Yi‐Ting Wang (ORCID: https://orcid.org/0000-0002-9130-5461)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Julie Ottoy (ORCID: https://orcid.org/0000-0002-9879-7497)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Gleb Bezgin (ORCID: https://orcid.org/0000-0002-1069-9201)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Serge Gauthier
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092616
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00