Longitudinal variability in resting heart rate associates with empathy decline in pre‐symptomatic and symptomatic familial frontotemporal degeneration
Changes in empathy in asymptomatic preFTD+ and FTD- are linked to variability in RHR regardless of genetic status, likely reflecting a non-specific impact of autonomic functioning on empathy and prosocial behavior. In contrast, increasing RHR predicts decline in cognitive and emotional empathy in FTD mutation carriers but primarily after phenoconversion, suggesting that autonomic contributions to empathy in familial FTD increase with disease progression and could be an early marker of manifest disease.
Authors
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Adam L. Boxer (ORCID: https://orcid.org/0000-0002-1215-5064)
- Emma Rhodes (ORCID: https://orcid.org/0000-0002-9053-0114)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Lauren Massimo (ORCID: https://orcid.org/0000-0002-3407-7335)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Virginia E. Sturm (ORCID: https://orcid.org/0000-0002-1717-298X)
- Laynie Dratch (ORCID: https://orcid.org/0000-0002-2179-3199)
- Howard J. Rosen (ORCID: https://orcid.org/0000-0001-9281-7402)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Katherine P. Rankin (ORCID: https://orcid.org/0000-0002-3611-0848)
Institutions
- Mayo Clinic (US)
- University of California, San Francisco (US)
- WinnMed (US)
- Left Hand Design (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091893
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00