Unraveling temporal transcription dynamics of molecular FTD and ALS subtypes
Our results revealed three data-driven molecular subtypes within the FTD-ALS spectrum with distinct patterns of early gene pathway involvement. This may contribute to further understanding of potential molecular mechanisms driving some of the heterogeneity and provides the first application of SuStaIn in identifying temporal dynamics of brain transcriptomics.
Authors
- Ting Shen (ORCID: https://orcid.org/0000-0002-3937-4427)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Vivianna M. Van Deerlin (ORCID: https://orcid.org/0000-0002-7400-9097)
- Hemali Phatnani (ORCID: https://orcid.org/0000-0002-6571-3891)
- Eddie B Lee
- Barbara E. Spencer (ORCID: https://orcid.org/0000-0002-1685-2967)
Institutions
- Institute for Neurodegenerative Disorders (US)
- New York Genome Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090423
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00