Persistent DNA damage response drives cGAS‐STING mediated neuroinflammation in a mouse model of tauopathy
These results offered strong evidence that tauopathy is linked to DNA DSB accumulation and/or changes in DNA repair proteins, which may have an impact on a critical initial step of the process, such as neuroinflammation, leading to neurodegeneration and memory loss.
Authors
- Jianfeng Xiao (ORCID: https://orcid.org/0000-0001-6865-4527)
- Himanshi Singh (ORCID: https://orcid.org/0009-0000-6213-5742)
- Mohammad Moshahid Khan (ORCID: https://orcid.org/0000-0003-4679-294X)
- Asmita Das (ORCID: https://orcid.org/0000-0001-9846-1005)
- Tayebeh Pourmotabbed (ORCID: https://orcid.org/0000-0003-3468-5880)
- Sazzad Khan
Institutions
- University of Tennessee Health Science Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093509
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00