Alzheimer’s disease histopathology in the human Down syndrome retina and in hiPSC‐derived retinal organoids

AD histopathology can be observed in the human DS retina and in stem cell-derived RO models of DS. These DS-RO models may open new opportunities for drug screening and biomarker discovery, as well as enable comparative pathophysiological studies between DS-ROs and the recently developed AD-ROs.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.093529
Primary Topic
Retinal Imaging and Analysis
Type
article
Field-Weighted Citation Impact
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article

Alzheimer’s disease histopathology in the human Down syndrome retina and in hiPSC‐derived retinal organoids

M. Natalia Vergara, Ethan James, Michael Ha, Citlali Aguilera‐Rico
Alzheimer s & Dementia
Retinal Imaging and Analysis
article

Alzheimer’s disease histopathology in the human Down syndrome retina and in hiPSC‐derived retinal organoids

M. Natalia Vergara, Ethan James, Michael Ha, Citlali Aguilera‐Rico
article en

Abstract

AD histopathology can be observed in the human DS retina and in stem cell-derived RO models of DS. These DS-RO models may open new opportunities for drug screening and biomarker discovery, as well as enable comparative pathophysiological studies between DS-ROs and the recently developed AD-ROs.

Alzheimer s & DementiaVol. 20(S1)
University of Colorado Anschutz Medical Campus (US)
Good health and well-being
Openalex Percentile: Top 58%
Retinal Imaging and Analysis
DOIOpen Access PDFOpenAlex
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Alzheimer’s disease histopathology in the human Down syndrome retina and in hiPSC‐derived retinal organoids — M. Natalia Vergara, Ethan James, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS